Association between active GB virus-C (hepatitis G) infection and HIV-1 disease in Uganda

Yirrell, D.L. and Wright, Edward and Shafer, L.A. and Campbell, E. and Van der Paal, Lieve and Kaleebu, Pontiano and Grosskurth, Heiner and Whitworth, J.A. (2007) Association between active GB virus-C (hepatitis G) infection and HIV-1 disease in Uganda. International Journal of STD & AIDS, 18 (4). pp. 244-249. ISSN 0956-4624

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Although not linked to a disease, GB virus-C viraemia has been associated with an improved prognosis in HIV-1-co-infected individuals. Most studies have been conducted on men (men who have sex with men or injection drug users) infected with HIV-1 subtype B, whereas here we report on both male and female subjects from rural Uganda, predominantly infected via the heterosexual route with HIV-1 subtypes A and D. In a longitudinal study of 272 participants, 47 were GBV-C positive and 181 negative, as determined by reverse transcription-polymerase chain reaction, in both of two plasma samples taken a median of 5.0 years apart. The remainder either acquired (25) or cleared (19) infection. Multilevel regression analyses and Cox survival analyses revealed that participants chronically infected with GBV-C had a slower decline in CD4+ T cells (P<0.001) and increased survival time (P=0.041) compared with GBV-C RNA-negative, HIV-positive adults. We show that the association between active GBV-C co-infection and improved survival of HIV-1-infected adults is not restricted to HIV subtype B, but is also observed in both males and females infected with HIV subtypes A and D.

Item Type: Article
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
Depositing User: Miss Nina Watts
Date Deposited: 04 Aug 2011 15:11
Last Modified: 04 Aug 2011 15:11

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