Association between active GB virus-C (hepatitis G) infection and HIV-1 disease in Uganda

Yirrell, D.L., Wright, Edward, Shafer, L.A., Campbell, E., Van der Paal, Lieve, Kaleebu, Pontiano, Grosskurth, Heiner and Whitworth, J.A. (2007) Association between active GB virus-C (hepatitis G) infection and HIV-1 disease in Uganda. International Journal of STD & AIDS, 18 (4). pp. 244-249. ISSN 0956-4624

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Official URL: http://dx.doi.org/10.1258/095646207780659006

Abstract

Although not linked to a disease, GB virus-C viraemia has been associated with an improved prognosis in HIV-1-co-infected individuals. Most studies have been conducted on men (men who have sex with men or injection drug users) infected with HIV-1 subtype B, whereas here we report on both male and female subjects from rural Uganda, predominantly infected via the heterosexual route with HIV-1 subtypes A and D. In a longitudinal study of 272 participants, 47 were GBV-C positive and 181 negative, as determined by reverse transcription-polymerase chain reaction, in both of two plasma samples taken a median of 5.0 years apart. The remainder either acquired (25) or cleared (19) infection. Multilevel regression analyses and Cox survival analyses revealed that participants chronically infected with GBV-C had a slower decline in CD4+ T cells (P<0.001) and increased survival time (P=0.041) compared with GBV-C RNA-negative, HIV-positive adults. We show that the association between active GBV-C co-infection and improved survival of HIV-1-infected adults is not restricted to HIV subtype B, but is also observed in both males and females infected with HIV subtypes A and D.

Item Type: Article
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
Depositing User: Miss Nina Watts
Date Deposited: 04 Aug 2011 15:11
Last Modified: 04 Aug 2011 15:11
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/9581

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