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The role of miRNA in diagnostics

Moschos, Sterghios A. (2010) The role of miRNA in diagnostics. International Drug Discovery, Online only . ISSN 2150-4792

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Abstract

Whilst the promise of RNA interference (RNAi) continues to expand in the therapeutic environment, the utility of the endogenous RNAi mechanism, microRNAs (miRNA), in diagnostics has been proven with the successful commercialization of a biopsy assay for the identification of cancer of unknown primary origin (CUP). The implications and consequences in personalized medicine arising from this highly sensitive and specific approach are substantial, however, the true potential is only beginning to be understood, as reports of disease-specific miRNA signatures in circulating lymphocytes, blood plasma/ serum, lung sputum, saliva and urine have been described, even in diseases where no diagnostic tools exist. This review summarizes the various approaches in miRNA biomarker discovery in addition to key findings in the field with the highest potential for clinical development.

Item Type:Article
Research Community:University of Westminster > Life Sciences, School of
ID Code:9723
Deposited On:15 Sep 2011 16:35
Last Modified:05 Feb 2013 09:25

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