WestminsterResearch

Targeting the lung using siRNA and antisense based oligonucleotides

Moschos, Sterghios A. and Spink, Karen G. and Williams, Andrew E. and Lindsay, Mark A. (2008) Targeting the lung using siRNA and antisense based oligonucleotides. Current Pharmaceutical Design, 14 (34). pp. 3620-3627. ISSN 1381-6128

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Abstract

The accessibility to topical administration through inhalation, combined with its large surface area, has led to speculation that the lung might offer an ideal target for the application of oligonucleotide based therapeutics. In this review, we shall critically examine the challenges facing antisense and siRNA based approaches for target validation in vivo and as potential therapeutics. In particular, we shall discuss the antisense and siRNA based approaches in relation to factors such as delivery, distribution, stability, off-target effects, unwanted immune responses and the selection of the optimum mRNA targets.

Item Type:Article
Research Community:University of Westminster > Life Sciences, School of
ID Code:9725
Deposited On:15 Sep 2011 16:46
Last Modified:15 Sep 2011 16:46

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