Targeting the lung using siRNA and antisense based oligonucleotides

Moschos, Sterghios A., Spink, Karen G., Williams, Andrew E. and Lindsay, Mark A. (2008) Targeting the lung using siRNA and antisense based oligonucleotides. Current Pharmaceutical Design, 14 (34). pp. 3620-3627. ISSN 1381-6128

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The accessibility to topical administration through inhalation, combined with its large surface area, has led to speculation that the lung might offer an ideal target for the application of oligonucleotide based therapeutics. In this review, we shall critically examine the challenges facing antisense and siRNA based approaches for target validation in vivo and as potential therapeutics. In particular, we shall discuss the antisense and siRNA based approaches in relation to factors such as delivery, distribution, stability, off-target effects, unwanted immune responses and the selection of the optimum mRNA targets.

Item Type: Article
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
Depositing User: Miss Nina Watts
Date Deposited: 15 Sep 2011 15:46
Last Modified: 15 Sep 2011 15:46

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