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Regional and molecular separation of the four bioactivities of ‘tribulin’

Hucklebridge, Frank and Doyle, Austin and Pang, Fung-Yin and Adlard, Max and Evans, Philip D. and Clow, Angela (1998) Regional and molecular separation of the four bioactivities of ‘tribulin’. Neuroscience Letters, 240 (1). pp. 29-32. ISSN 0304-3940

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Official URL: http://dx.doi.org/10.1016/S0304-3940(97)00916-6

Abstract

The endocoid tribulin has four known bioactivities: monoamine oxidase A and B inhibitory activities (MAO-AI and MAO-BI) and peripheral and central benzodiazepine receptor binding inhibitory activities (PBR-I and CBR-I). Analysis of the four bioactivities in rat tissue reveals regional dissociation. Most notably liver was particularly rich in PBR-I yet contained no detectable MAO-AI. In addition we have succeeded in separating the four activities from human urine. MAO-AI and MAO-BI have greater retention on charcoal than PBR-I and CBR-I when eluted step-wise with aqueous methanol. MAO-AI can be separated from MAO-BI and in addition PBR-I can be separated from CBR-I by step aqueous methanol elution from Amberlite XAD-4. Hence we present two lines of evidence that, contrary to the original view, tribulin is composed of a number of distinct molecular components.

Item Type:Article
Research Community:University of Westminster > Social Sciences, Humanities and Languages, School of
ID Code:9933
Deposited On:07 Dec 2011 12:05
Last Modified:07 Dec 2011 12:05

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