WestminsterResearch

Salivary monoamine oxidase A and B inhibitory activities correlate with stress

Doyle, A. and Hucklebridge, Frank and Evans, Philip D. and Clow, Angela (1996) Salivary monoamine oxidase A and B inhibitory activities correlate with stress. Life Sciences, 59 (16). pp. 1357-1362. ISSN 0024-3205

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Official URL: http://dx.doi.org/10.1016/0024-3205(96)00461-4

Abstract

MAO A and B inhibitory activities were determined. for the first time, in saliva samples. Saliva was collected on 4 occasions from 11 normal subjects (students) before and after delivering an important assessed oral presentation, a naturalistic stress inducing procedure. The first sample was collected 30 minutes before the presentation and 3 more within 40 minutes of finishing the presentation. At each collection a mood adjective checklist was completed. Mean MAO A inhibitory activity correlated with mean MAO B inhibitory activity (r = 0.872, p < 0.001. n = 11). Within subject analysis revealed a positive correlation between MAO A and B inhibitory activity and stress (r = 0.400, p < 0.01, n = 44 and r = 0.255, NS, n = 38 respectively). Mean MAO A and B inhibitory activity correlated with mean stress (r = 0.535, NS, n = 11 and r = 0.673, p < 0.05, n = 11 respectively). Peak MAO A and B inhibitory activities correlated with peak stress (r = 0.636, p < 0.05, n = 11 and r = 0.754, p < 0.01, n = 11, respectively). Salivary MAO A and B inhibitory activities were independent of salivary flow rate. We conclude that measurement of MAO A and B inhibitory activities in saliva is preferable to traditional urinary measures as sampling is less invasive and also supports a clear relationship to stress in normal individuals.

Item Type:Article
Research Community:University of Westminster > Social Sciences, Humanities and Languages, School of
ID Code:9944
Deposited On:07 Dec 2011 12:00
Last Modified:07 Dec 2011 12:00

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