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The effect of pergolide and MDL 72974 on rat brain CuZn superoxide dismutase

Clow, Angela and Freestone, Clare and Lewis, Emma and Dexter, David and Sandler, Merton and Glover, Vivette (1993) The effect of pergolide and MDL 72974 on rat brain CuZn superoxide dismutase. Neuroscience Letters, 164 (1-2). pp. 41-43. ISSN 0304-3940

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Official URL: http://dx.doi.org/10.1016/0304-3940(93)90852-C

Abstract

It has previously been shown that both the dopamine receptor agonist, pergolide, and the monoamine oxidase inhibitor. (−)-deprenyl, can cause induction of CuZn superoxide dismutase in the rat striatum. We have now confirmed this effect of pergolide (0.04 mg/kg i.p.) as being localised to the striatum, but not the cerebellum, and shown it to take 3 weeks to develop. Furthermore, we have found that MDL 72974, a more specific monoamine oxidase inhibitor than (−)-deprenyl, failed to bring about such an induction either at a low selective monoamine oxidase B inhibitory dose, or at a higher non-selective dose.

Item Type:Article
Research Community:University of Westminster > Social Sciences, Humanities and Languages, School of
ID Code:9951
Deposited On:07 Dec 2011 11:57
Last Modified:07 Dec 2011 11:57

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