Effects of dopaminergic drugs on superoxide dismutase: implications for senescence

Glover, V. and Clow, Angela and Sandler, M. (1993) Effects of dopaminergic drugs on superoxide dismutase: implications for senescence. Journal of Neural Transmission (supplement) , 40. pp. 37-45. ISSN 0303-6995

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Abstract

Both (-)-deprenyl and pergolide have been found to induce superoxide dismutase (SOD) in rat striata. There are several reports showing that strains or species with higher levels of SOD live longer. Other studies indicate that (-)-deprenyl can increase life expectancy in rats and that both (-)-deprenyl and pergolide may retard nigrostriatal degeneration. This present paper suggests that all these findings are linked, and that (-)-deprenyl and pergolide possess neuroprotective properties by virtue of an activated removal of toxic oxygen radicals.

Item Type: Article
Subjects: University of Westminster > Social Sciences and Humanities
Depositing User: Rachel Wheelhouse
Date Deposited: 07 Dec 2011 11:57
Last Modified: 07 Dec 2011 11:57
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/9953

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