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Pergolide can induce soluble Superoxide dismutase in rat striata

Clow, Angela and Hussain, T. and Glover, Vivette and Sandler, M. and Walker, Martin and Dexter, D. (1992) Pergolide can induce soluble Superoxide dismutase in rat striata. Journal of Neural Transmission, 90 (1). pp. 27-31. ISSN 0300-9564

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Official URL: http://dx.doi.org/10.1007/BF01250515


Pergolide, a dopamine receptor agonist, given daily i.p. for three weeks at 0.04mg/kg and 0.4mg/kg, significantly induced soluble (Cu-Zn) superoxide dismutase in the rat striatum, while having no effect on the mitochondrial (Mn) form of the enzyme. Such induction, which can also be effected by (–)-deprenyl, may help to protect against nigrostriatal degeneration.

Item Type:Article
Research Community:University of Westminster > Social Sciences, Humanities and Languages, School of
ID Code:9957
Deposited On:07 Dec 2011 11:55
Last Modified:28 Aug 2014 14:29

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