Pergolide can induce soluble Superoxide dismutase in rat striata

Clow, Angela and Hussain, T. and Glover, Vivette and Sandler, M and Walker , M and Dexter, D (1992) Pergolide can induce soluble Superoxide dismutase in rat striata. Journal of Neural Transmission, 90 (1). pp. 27-31. ISSN 0300-9564

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Official URL: http://dx.doi.org/10.1007/BF01250515


Pergolide, a dopamine receptor agonist, given daily i.p. for three weeks at 0.04mg/kg and 0.4mg/kg, significantly induced soluble (Cu-Zn) superoxide dismutase in the rat striatum, while having no effect on the mitochondrial (Mn) form of the enzyme. Such induction, which can also be effected by (–)-deprenyl, may help to protect against nigrostriatal degeneration.

Item Type:Article
Research Community:University of Westminster > Social Sciences, Humanities and Languages, School of
ID Code:9957
Deposited On:07 Dec 2011 11:55
Last Modified:07 Dec 2011 11:55

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