Inhibitory potency of some isatin analogues on human monoamine oxidase A and B

Medvedev, Alexei and Goodwin, Brian and Clow, Angela and Halket, John and Glover, Vivette and Sandler , M. (1992) Inhibitory potency of some isatin analogues on human monoamine oxidase A and B. Biochemical Pharmacology, 44 (3). pp. 590-592. ISSN 0006-2952

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Official URL: http://dx.doi.org/10.1016/0006-2952(92)90454-Q

Abstract

Isatin is an endogenous compound which acts as a selective inhibitor of monoamine oxidase (MAO) B. In this study a range of isatin analogues were tested for their in vitro inhibition of human MAO A and B. Most of the analogues were less potent than isatin. Hydroxylation of the aromatic ring changed the inhibitory potency in favour of MAO A, with 5-hydroxyisatin being a potent and selective MAO A inhibitor (ic50 8?M). Isatinic acid, which is formed reversibly from isatin at alkaline pH, showed no inhibition.

Item Type: Article
Subjects: University of Westminster > Social Sciences and Humanities
Depositing User: Rachel Wheelhouse
Date Deposited: 07 Dec 2011 11:55
Last Modified: 07 Dec 2011 11:55
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/9958

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