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(−)-Deprenyl can induce soluble superoxide dismutase in rat striata

Clow, Angela and Hussain, T. and Glover, Vivette and Sandler, M. and Dexter, D. and Walker, M. (1991) (−)-Deprenyl can induce soluble superoxide dismutase in rat striata. Journal of Neural Transmission, 86 (1). pp. 77-80. ISSN 0300-9564

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Official URL: http://dx.doi.org/10.1007/BF01250378


(–)-Deprenyl (0.25 or 2mg/kg) or saline was injected daily into male Wistar rats for 3 weeks. The striata were dissected out and soluble and particulate Superoxide dismutase activity measured. (–)-Deprenyl at 2mg/kg induced a significant increase in the soluble but not the particulate form of the enzyme. The possibility that this action contributes to the ability of (–)-deprenyl to retard nigral degeneration in man and prolong life in rats is discussed.

Item Type:Article
Research Community:University of Westminster > Social Sciences, Humanities and Languages, School of
ID Code:9959
Deposited On:07 Dec 2011 11:55
Last Modified:28 Aug 2014 14:30

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