Effect of aromatic amino acids, pentylenetetrazole and yohimbine on isatin and tribulin activity in rat brain

Bhattacharya, S.K. and Clow, Angela and Przyborowska, A. and Halket, J. and Glover, Vivette and Sandler, M. (1991) Effect of aromatic amino acids, pentylenetetrazole and yohimbine on isatin and tribulin activity in rat brain. Neuroscience Letters, 132 (1). pp. 44-46. ISSN 0304-3940

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Official URL: http://dx.doi.org/10.1016/0304-3940(91)90429-W

Abstract

The effects of i.p. injection of 3 aromatic amino acids and two anxiogenic agents on rat brain isatin concentration and tribulin (endogenous monoamine oxidase inhibitor) activity were investigated. Isatin levels were significantly increased by pentylenetetrazole, confirming the link with ‘anxiety’, but were unaffected by the other compounds. In contrast, tribulin activity was significantly increased by phenylalanine and tryptophan, as well as by both pentylenetetrazole and yohimbine. Whilst these findings shed no light on the mode of synthesis of isatin, they clearly demonstrate the existence of rat brain monoamine oxidase inhibitory activity that is different from it.

Item Type: Article
Subjects: University of Westminster > Social Sciences and Humanities
Depositing User: Rachel Wheelhouse
Date Deposited: 07 Dec 2011 11:55
Last Modified: 07 Dec 2011 11:55
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/9960

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