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Stress reduces in vivo inhibition of monoamine oxidase by phenelzine in rat brain

Clow, Angela and Glover, Vivette and Oxenkrug, G.F. and Sandler, M. (1989) Stress reduces in vivo inhibition of monoamine oxidase by phenelzine in rat brain. Neuroscience Letters, 107 (1-3). pp. 331-334. ISSN 0304-3940

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Official URL: http://dx.doi.org/10.1016/0304-3940(89)90841-0

Abstract

The level of inhibition of rat whole brain monoamine oxidase activity produced by the irreversible monoamine oxidase inhibitor phenelzine has been studied with or without concurrent cold restraint stress. We have found that phenelzine caused significantly less enzyme inhibition when given during a period of stress than during a control period. Thus, stress can reduce the in vivo potency of MAO inhibitors. This would be compatible with an increased production of the reversible, endogenous monoamine oxidase inhibitor, tribulin, competing for the active site of the enzyme.

Item Type:Article
Research Community:University of Westminster > Social Sciences, Humanities and Languages, School of
ID Code:9963
Deposited On:07 Dec 2011 11:53
Last Modified:07 Dec 2011 11:53

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