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Isatin and tribulin concentrations are increased in rabbit brain but not liver following pentylenetetrazole administration

Clow, Angela and Davidson, J. and Glover, Vivette and Halket, J.M. and Milton, A.S. and Sandler, M. and Watkins, P.J. (1989) Isatin and tribulin concentrations are increased in rabbit brain but not liver following pentylenetetrazole administration. Neuroscience Letters, 107 (1-3). pp. 327-330. ISSN 0304-3940

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Official URL: http://dx.doi.org/10.1016/0304-3940(89)90840-9

Abstract

Isatin has recently been identified in rat tissues and normal human urine where it constitutes the major part of the endogenous monoamine oxidase inhibitor, tribulin. In this study, we have measured both isatin (by gas chromatography/mass spectrometry) and tribulin (inhibition of a standard rat liver monoamine oxidase preparation) in extracts of rabbit brains and livers after intravenous administration of the anxiogenic, proconvulsant agent pentylenetetrazole. There were increased levels of both isatin and tribulin in rabbit brains, but not in livers, after pentylenetetrazole, compared with saline treated controls. This finding supports the hypothesis that isatin is a component of tribulin activity and may have a role in anxiety or epilepsy.

Item Type:Article
Research Community:University of Westminster > Social Sciences, Humanities and Languages, School of
ID Code:9964
Deposited On:07 Dec 2011 11:53
Last Modified:07 Dec 2011 11:53

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