Isatin: identity with the purified endogenous monoamine oxidase inhibitor tribulin

Glover, Vivette and Halket, J.M. and Watkins, P.J. and Clow, Angela and Goodwin, B.L. and Sandler, M. (1988) Isatin: identity with the purified endogenous monoamine oxidase inhibitor tribulin. Journal of Neurochemistry , 51 (2). pp. 656-659. ISSN 0022-3042

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Official URL: http://dx.doi.org/10.1111/j.1471-4159.1988.tb01089...

Abstract

Purified tribulin, an endogenous monoamine oxidase (MAO) inhibitor, has been identified by direct probe insertion mass spectrometry as the indole-2,3-dione, isatin. A gas chromatographic-mass spectrometric assay for isatin has been developed and used to measure its relatively high concentrations in unpurified human urine, and in rat heart and brain. Isatin is a known compound with a broad range of biological activity; this is the first report of its presence in the animal body. Isatin is a potent inhibitor of MAO, particularly of MAO B (IC50, 3 ?M), and also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 ?M).

Item Type: Article
Subjects: University of Westminster > Social Sciences and Humanities
Depositing User: Rachel Wheelhouse
Date Deposited: 07 Dec 2011 11:52
Last Modified: 07 Dec 2011 11:52
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/9966

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