Elsworth, J.D. and Dewar, D. and Glover, Vivette and Goodwin, B.L. and Clow, Angela and Sandler , M. (1986) Purification and characterization of tribulin, an endogenous inhibitor of monoamine oxidase and of benzodiazepine receptor binding. Journal of Neural Transmission, 67 (1-2). pp. 45-56. ISSN 0300-9564
Full text not available from this repository.
Official URL: http://dx.doi.org/10.1007/BF01243358
A low molecular weight fraction of human urine (less than 500 daltons) which both inhibits monoamine oxidase and benzodiazepine binding to central and peripheral receptors has been purified by ethyl acetate extractions, HPLC and thin layer chromatography. This material extracted equally well at acid and basic pH and was insoluble in heptane. It competitively inhibited binding of 3H-clonazepam, a central benzodiazepine receptor agonist and, in addition, displaced 3H-Ro 5-4864, a specific peripheral benzodiazepine receptor ligand, from its binding sites. It showed no GABA shift with the benzodiazepine receptor antagonist, Ro-15 1788. MAO A and B were inhibited approximately equipotently and the material competitively inhibited tyramine oxidation by rat liver. It was stable on boiling and is unlikely to be a peptide.
|Research Community:||University of Westminster > Social Sciences, Humanities and Languages, School of|
|Deposited On:||07 Dec 2011 11:48|
|Last Modified:||07 Dec 2011 11:48|
Repository Staff Only: item control page