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Items where Author is Locke, Ian C.

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Number of items: 54.

2013

Basnett, Pooja and Ching, K.Y. and Stolz, M. and Knowles, Jonathan C. and Boccaccini, Aldo R. and Smith, Caroline L. and Locke, Ian C. and Keshavarz, Tajalli and Roy, Ipsita (2013) Novel Poly(3-hydroxyoctanoate)/Poly(3-hydroxybutyrate) blends for medical applications. Reactive and Functional Polymers, 73 (10). pp. 1340-1348. ISSN 1381-5148

Intekhab Alam, Nabila Yasmin and White, Omeco Bianco and Getting, Stephen J. and Petsa, A. and Knight, Richard A. and Townsend, Paul A. and Lawrence, Kevin M. and Locke, Ian C. (2013) Urocortin protects chondrocytes from NO-induced apoptosis: a future therapy for osteoarthritis? Cell Death and Disease, 4 . e717. ISSN 2041-4889

Ashioti, Maria and Getting, Stephen J. and Locke, Ian C. and Milton, Nathaniel G.N. (2013) Neuroprotective efficacy of the endogenous neuropeptide Urocortin in a oxygen-glucose deprivation model of transient cerebral ischaemia with reperfusion. In: British Neuroscience Association 22nd Biennial Meeting, 7th-10th April 2013, London.

Basnett, Pooja and Ching, K.Y. and Stolz, M. and Knowles, Jonathan C. and Boccaccini, Aldo R. and Smith, Caroline L. and Locke, Ian C. and Roy, Ipsita (2013) Aspirin-loaded P(3HO)/P(3HB) blend films: potential materials for biodegradable drug-eluting stents. Bioinspired, Biomimetic and Nanobiomaterials, 2 (3). pp. 141-153. ISSN 2045-9858

2012

Kaneva, Magdalena and Kerrigan, Mark J.P. and Grieco, Paolo and Curley, G. Paul and Locke, Ian C. and Getting, Stephen J. (2012) Chondroprotective and anti-inflammatory role of melanocortin peptides in TNF-α activated human C-20/A4 chondrocytes. British Journal of Pharmacology, 167 (1). pp. 67-79. ISSN 0007-1188

Combs, Charlotte and Fuller, Karen and Kumar, Hashethra and Albert, Anthony P. and Pirianov, Grisha and McCormick, James and Locke, Ian C. and Chambers, Timothy J. and Lawrence, Kevin M. (2012) Urocortin is a novel regulator of osteoclast differentiation and function through inhibition of a canonical transient receptor potential 1-like cation channel. Journal of Endocrinology, 212 (2). pp. 187-197. ISSN 0022-0795

Can, Vedia and Kaneva, Magdalena and Kerrigan, Mark J.P. and Locke, Ian C. and Getting, Stephen J. (2012) The anti-inflammatory effects of melanocortin peptides in lipopolysaccharide activated chondrocytes. In: British Phamacological Society Winter Meeting 2012, 18th-20th December, London, UK.

2011

Rai, Ranjana and Boccaccini, Aldo R. and Knowles, Jonathan C. and Mordon, Nicola and Salih, Vehid and Locke, Ian C. and Moshrefi-Torbati, M. and Keshavarz, Tajalli and Roy, Ipsita (2011) The homopolymer poly(3-hydroxyoctanoate) as a matrix material for soft tissue engineering. Journal of Applied Polymer Science, 122 (6). pp. 3606-3617. ISSN 0021-8995

Kaneva, Magdalena and Kerrigan, Mark J.P. and Locke, Ian C. and Getting, Stephen J. (2011) α-MSH and [DTRP]8-γ-MSH inhibit pro-inflammatory cytokine release from stimulated primary bovine chondrocytes. In: 10th World Congress on Inflammation, 25–29 June 2011, Paris, France.

Kaneva, Magdalena and Kerrigan, Mark J.P. and Locke, Ian C. and Getting, Stephen J. (2011) MC1 and MC3 activation inhibits caspase-3 production and activity, promotes cell-viability, and induces IL-10 and HO-1 release from human C20/A4 chondrocytes. In: Physiological Society Meeting 23, University of Oxford.

White, O.B and Intekhab-Alam, N.Y. and Chowdrey, H.S. and Knight, R.A. and Locke, Ian C. (2011) Chondrocyte CRF receptor expression and Urocortin I mediated chondroprotection. In: Rheumatology 2011, 12th-14th April 2011, Brighton, UK.

2010

Kaneva, Magdalena and Kerrigan, Mark J.P. and Locke, Ian C. and Getting, Stephen J. (2010) Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells. In: British Orthopaedic Research Society Annual Meeting, 22 - 23 Jun 2009, Newcastle upon Tyne.

Kaneva, Magdalena and Locke, Ian C. and Kerrigan, Mark J.P. and Getting, Stephen J. (2010) α-MSH and dTRP8-γ-MSH inhibit TNF-α induced MMP 1 and 13 expression in human C20/A4 chondrocytes. In: British Pharmacological Society Winter Meeting 2010, 14th-16th December 2010, London, UK.

Kaneva, Magdalena and Kerrigan, Mark J.P. and Locke, Ian C. and Getting, Stephen J. (2010) The MC3 agonist dTRP8-γ-MSH inhibits IL-6 and IL-8 release from TNF-α stimulated C-20/A4 chondrocytes, an effect blocked by the MC3R antagonist SHU9119. In: Physiology 2010, 30 June - 2 July 2010, University of Manchester.

Rai, Ranjana and Boccaccini, Aldo R. and Knowles, Jonathan C. and Locke, Ian C. and Gordge, Michael P. and McCormick, Aine and Salih, Vehid and Mordon, Nicola and Keshavarz, Tajalli and Roy, Ipsita (2010) Fabrication of a novel poly(3-hydroxyoctanoate) / nanoscale bioactive glass composite film with potential as a multifunctional wound dressing. In: 5th international conference on times of polymers (TOP) and composites, 20–23 June 2010 , Ischia, Italy.

Francis, Lydia and Meng, Decheng and Locke, Ian C. and Mordon, Nicola and Salih, Vehid and Knowles, Jonathan C. and Boccaccini, Aldo R. and Roy, Ipsita (2010) The influence of tetracycline loading on the surface morphology and biocompatibility of films made from P(3HB) microspheres. Advanced Engineering Materials, 12 (7). B260-B268. ISSN 1438-1656

White, O.B and Intekhab-Alam, N.Y. and Chowdrey, H.S. and Knight, R.A. and Locke, Ian C. (2010) Mechanisms of Urocortin family peptide mediated chondroprotection. In: OARSI 2010 World Congress on Osteoarthritis, September 23-26, 2010, Brussels, Belgium.

Locke, Ian C. and White, O.B and Trwoga, P.F. and Afoke, A.N. (2010) The effect of indentor shape on the creep curves of collagen gel. In: OARSI 2010 World Congress on Osteoarthritis, September 23-26, 2010, Brussels, Belgium.

2009

Getting, Stephen J. and Kaneva, Magdalena and Bhadresa, Y. and Renshaw, Derek and Leoni , Giovanna and Patel, H.B. and Kerrigan, Mark J.P. and Locke, Ian C. (2009) Melanocortin peptide therapy for the treatment of arthritic pathologies. The Scientific World Journal, 9 . pp. 1394-1414. ISSN 1537-744X

Kaneva, Magdalena and Kerrigan, Mark J.P. and Locke, Ian C. and Getting, Stephen J. (2009) Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells. pA2 Online. From the Queen Elizabeth II Conference Centre London, Winter 2009 Meeting: Proceedings of the British Pharmacological Society . 126P. ISSN 1741-1157

Kaneva, Magdalena and Kerrigan, Mark J.P. and Locke, Ian C. and Getting, Stephen J. (2009) Pro-inflammatory mediator release from TNF-α stimulated C-20/A4 cells results in Col II degradation. In: British Orthopaedic Research Society (BORS) Annual Meeting, 22nd - 23rd June 2009, Newcastle.

2007

Shah, Chirag M. and Bell, Susannah E. and Locke, Ian C. and Chowdrey, Hardial S. and Gordge, Michael P. (2007) Interactions between cell surface protein disulphide isomerase and S-nitrosoglutathione during nitric oxide delivery. Nitric Oxide, 16 (1). pp. 135-142. ISSN 1089-8603

Abuirmeileh, Amjad and Lever, Rebecca and Kingsbury, Ann E. and Lees, Andrew J. and Locke, Ian C. and Knight, Richard A. and Chowdrey, Hardial S. and Biggs, Christopher S. and Whitton, Peter S. (2007) The corticotrophin-releasing factor-like peptide urocortin reverses key deficits in two rodent models of Parkinson's disease. European Journal of Neuroscience, 26 (2). pp. 417-423. ISSN 0953-816X

2006

Curras Lino, M. and Radman, Romeo and Bertaud, F. and Nisula, L. and Lenon, G. and Holbom, B. and Locke, Ian C. and Thompson, S. and Keshavarz, Tajalli (2006) Biological activity of industrial wood and bark waste from Pinus nigra. In: Actual problems of creation of new medicinal preparations of natural origin: the 10th international congress PHYTOPHARM 2006, St.-Petersburg, June 27-30, 2006: proceedings of congress. PHYTOPHARM, St Petersburg, Russia, pp. 401-403.

Prashar, Anjali and Locke, Ian C. and Evans, Christine S. (2006) Cytotoxicity of clove (Syzygium aromaticum) oil and its major components to human skin cells. Cell Proliferation, 39 (4). pp. 241-248. ISSN 0960-7722

2005

Biggs, Christopher S. and Locke, Ian C. and Knight, Richard A. and Chowdrey, Hardial S. and Whitton, Peter S. (2005) Evidence for a neuroprotective role of the CRH-like peptide, urocortin, in the 6-hydroxydopamine treated rat. In: 18th National Meeting of the British Neuroscience Association, 03-06 Apr 2005, Brighton, UK. (Submitted)

Biggs, Christopher S. and Abuirmeileh, Amjad and Locke, Ian C. and Knight, Richard A. and Chowdrey, Hardial S. and Whitton, Peter S. (2005) Urocortin attenuates key indicators of nigrostriatal pathway destruction in a rat hemiparkinsonian model. Proceedings of the British Pharmacological Society, 3 (4).

Shah, Chirag M. and Walters, S.E. and Locke, Ian C. and Chowdrey, Hardial S. and Gordge, Michael P. (2005) Interactions between cell surface protein disulphide isomerase and S-nitrosoglutathione during nitric oxide delivery into MEG-01 megakaryocytes. In: Ireland-UK Platelet Conference 2005, 04-06 Sep 2005, Dublin, Ireland. (Submitted)

2004

Prashar, Anjali and Locke, Ian C. and Evans, Christine S. (2004) Cytotoxicity of lavender oil and its major components to human skin cells. Cell Proliferation, 37 (3). pp. 221-229. ISSN 0960-7722

Locke, Ian C. and Carpenter, Brian (2004) Functional characteristics of the streptococcal deoxyribonuclease 'streptodornase', a protein with DNase activity present in the medicament Varidase. Enzyme and Microbial Technology, 35 (1). pp. 67-73. ISSN 0141-0229

Shah, C.M. and Locke, Ian C. and Chowdrey, Hardial S. and Gordge, Michael P. (2004) Cell surface thiol modification by GSNO: a mechanism of nitric oxide delivery? In: 5th UK Nitric Oxide Forum, 12/2004, Edinburgh, UK. (Submitted)

Intekhab-Alam, N.Y. and Chowdrey, Hardial S. and Knight, R.A. and Locke, Ian C. (2004) A CRH family peptide protects a human chondrocyte cell line against apoptosis. In: OARSI 2004 World Congress on Osteoarthritis, 12/2004, Chicago USA.

Petsa, A. and Chowdrey, H.S. and Knight, R.A. and Afoke, A.N. and Locke, Ian C. (2004) Establishment and analysis of 3-D collagen cultures of C-20/A4 chondrocytes. In: OARSI 2004 World Congress on Osteoarthritis, 12/2004, Chicago USA.

Shah, C.M. and Locke, Ian C. and Chowdrey, H.S. and Gordge, M.P. (2004) Protein disulphide isomerase is involved in the delivery of NO from S-nitrosoglutathione into megakaryocytes. In: Japan-UK Platelet Conference, September 2004, Oxford, UK. (Submitted)

Shah, C.M. and Locke, Ian C. and Chowdrey, H.S. and Gordge, M.P. (2004) Protein disulphide isomerase is involved in the delivery of NO from S-nitrosoglutathione into megakaryocytes. In: 3rd International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide: 4th Anuual Scientific Meeting of the Nitric Oxide Society of Japan, 24-28 May 2004, Nara, Japan.

2003

Shah, Chirag M. and Locke, Ian C. and Chowdrey, Hardial S. and Gordge, Michael P. (2003) Rapid S-nitrosothiol metabolism by platelets and megakaryocytes. Biochemical Society Transactions, 31 (6). pp. 1450-1452. ISSN 0300-5127

Shah, C.M. and Locke, Ian C. and Chowdrey, Hardial S. and Gordge, Michael P. (2003) Role of protein disulphide isomerase in NO delivery from S-nitrosothiols into megakaryocytes. In: 4th UK Nitric Oxide Forum, December 2003, University of Nottingham, UK. (Submitted)

Petsa, A. and Afoke, A.N. and Chowdrey, H.S. and Knight, R.A. and Harris, A.B. and Locke, Ian C. (2003) The behaviour of C-20/A4 chondrocytes in 3-D collagen gel cultures. In: OARSI 2003 World Congress on Osteoarthritis, October 2003, Berlin, Germany.

2002

Locke, Ian C. and Carpenter, Brian (2002) Ion-dependency of the streptococcal deoxyribonuclease "streptodornase", an active constituent of the medicament Varidase. Enzyme and Microbial Technology, 31 (4). pp. 482-489. ISSN 0141-0229

Prashar, A. and Veness, R.G. and Locke, Ian C. and Evans, C.S. (2002) Effect of essential oils and their components on cell. In: Future Trends in Phytochemistry, Gargnano, Italy. (Submitted)

2000

Rutter, P.M. and Carpenter, B. and Hill, S.S. and Locke, Ian C. (2000) Varidase: the science behind the medicament. Journal of Wound Care, 9 (5). pp. 223-226. ISSN 0969-0700

1999

Locke, Ian C. and Leaker, B. and Cambridge, G. (1999) A comparison of the characteristics of circulating anti-myeloperoxidase antibodies in vasculitis with those in non-vasculitic conditions. Clinical and Experimental Immunology, 115 (2). pp. 369-376. ISSN 0009-9104

1998

Liu, Yu-Zhen and Lee, Il-Kwon and Locke, Ian C. and Dawson, Sally J. and Latchman, David (1998) Adjacent proline residues in the inhibitory domain of the Oct-2 transcription factor play distinct functional roles. Nucleic Acids Research, 26 (10). pp. 2464-2472. ISSN 0305-1048

Locke, Ian C. and Rahman, M.A.A. and Cambridge, G. (1998) A comparison of the variable region genes of two human monoclonal antibodies to myeloperoxidase. In: British Society for Immunology 6th Annual Meeting, 12/1998, Harrogate, UK.

1997

Locke, Ian C. and Cox, S.F. and Carpenter, B.G. (1997) Purification of a streptococcal deoxyribonuclease by affinity chromatography based on a DNA-cellulose matrix. Journal of Chromatography A, 788 (1-2). pp. 75-80. ISSN 0021-9673

Locke, Ian C. and Worral, J.G. and Leaker, B. and Black, C.M. and Cambridge, G. (1997) Autoantibodies to myeloperoxidase in systemic sclerosis. Journal of Rheumatology, 24 (1). pp. 86-89. ISSN 0315-162X

1996

Locke, Ian C. and Cambridge, G. (1996) Autoantibodies to neutrophil granule proteins: pathogenic potential in vasculitis? British Journal of Biomedical Science, 53 (4). pp. 302-316. ISSN 0967-4845

Cambridge, G. and Leaker, B. and Locke, Ian C. and Noronha Dutra, A. and Epperlein, M. (1996) A human monoclonal anti-myeloperoxidase antibody can prime human neutrophils in vitro. In: American Society of Nephrology 29th Annual Meeting, 11/1996, New Orleans, USA.

Locke, Ian C. and Leaker, B. and Cambridge, G. (1996) Characteristics of anti-myeloperoxidase autoantibodies in vasculitis and other conditions. In: American Society of Nephrology 29th Annual Meeting, 11/1996, New Orleans, USA.

Locke, Ian C. and Leaker, B. and Cambridge, G. (1996) Characteristics of antibodies to myeloperoxidase in vasculitic and non-vasculitic conditions. In: American College of Rheumatology 60th National Scientific Meeting , 10/1996, Orlando, USA.

1995

Worral, J.G. and Locke, Ian C. and Leaker, B. and Black, C.M. and Cambridge, G. (1995) Autoantibodies to myeloperoxidase in systemic sclerosis. In: British Society for Rheumatology Heberden Round 1995, 9/1995, Keele University, UK.

1993

Locke, Ian C. and Ramsay, M.P. and Hill, S.S. and Carpenter, B.G. (1993) Automated analysis of the deoxyribonuclease active constituents of the medicament Varidase ®. The Journal of Automatic Chemistry, 15 . pp. 65-70. ISSN 2090-8865

1992

Locke, Ian C. and Ramsey, M.P. and Hill, S.S. and Carpenter, B.G. (1992) Automated analysis of the deoxyribonuclease active constituents of the medicament Varidase ®. In: IMLS XX Triennial Conference, 9/1992, Liverpool, UK.

1990

Rogers, D.J. and Locke, Ian C. and Gibbs, R. and Carpenter, B.G. (1990) Purification of the seed lectin from Dolichos biflorus by chromatofocusing. In: 12th International Lectin Conference, 9/1990, University of Davis, USA. (Submitted)

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